HitPredict

Interactor 1: TRAF5 (O00463)
TNF receptor-associated factor 5 (RING finger protein 84)
Gene: TRAF5

Interactor 2: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17384642
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 557 Hs			1 606
+	Hs
		201322 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Hs
		201318 TRAF2_HUMAN (28-554): 1.19e-102: 320: 31.66		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Mm
		761816 TRAF2_MOUSE (28-554): 5.26e-102: 318: 33.46		M3K7_MOUSE (1-606): 0: 545: 94.88
+	Rn
		78178 TRAF6_RAT (21-551): 2.93e-82: 268: 22.39		M3K7_RAT (1-606): 0: 573: 99.01
+	Hs
		201483 TRAF6_HUMAN (21-551): 1.31e-81: 266: 22.02		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Hs
		201418 TRAF4_HUMAN (29-551): 2.98e-73: 243: 23.32		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Mm
		936234 TRAF6_MOUSE (21-551): 2.76e-83: 271: 22.20		M3K7_MOUSE (1-606): 0: 545: 94.88
+	Hs
		201197 TRI27_HUMAN (32-469): 5.05e-69: 233: 10.97		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Hs
		135003 TRI38_HUMAN (32-468): 3.82e-65: 221: 10.67		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Hs
		201335 TRI25_HUMAN (38-387): 1.04e-43: 166: 15.43		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Hs
		983596 TRAF2_HUMAN (28-554): 1.19e-102: 320: 31.66		FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04
+	Hs
		872432 TRAF2_HUMAN (28-554): 1.19e-102: 320: 31.66		EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27
+	Hs
		1021002 TRAF2_HUMAN (28-554): 1.19e-102: 320: 31.66		RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29
+	Hs
		1052836 TRAF4_HUMAN (29-551): 2.98e-73: 243: 23.32		FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58
+	Hs
		129565 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27
+	Hs
		1377873 TRAF6_HUMAN (21-551): 1.31e-81: 266: 22.02		RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29
+	Dm
		1359091 Q9XYR0_DROME (151-554): 3.12e-59: 206: 24.82		M3K7_DROME (31-593): 6.48e-121: 374: 33.06
+	Hs
		1020685 TRAF2_HUMAN (28-554): 1.19e-102: 320: 31.66		M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27
+	Mm
		761825 TRAF2_MOUSE (28-554): 5.26e-102: 318: 33.46		M3K11_MOUSE (29-287): 6.85e-37: 149: 35.27
+	Hs
		1083527 TRAF6_HUMAN (21-551): 1.31e-81: 266: 22.02		M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27