HitPredict

Interactor 1: TRAF5 (O00463)
TNF receptor-associated factor 5 (RING finger protein 84)
Gene: TRAF5

Interactor 2: TNR5 (P25942)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
Gene: CD40

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	12220533, 20614026, 26779844, 9990007, 8790348, 11562359, 21041727, 9511754, 20676093, 17332487, 9718306
Identification Methods	affinity chromatography technology, unspecified method, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding GO:0035631 - CD40 receptor complex GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 557 Hs			1 277
+	Hs
		129607 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87
+	Mm
		192584 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09
+	Mm
		648958 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR5_MOUSE (1-277): 2.29e-81: 248: 60.43
+	Mm
		936208 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		TNR14_MOUSE (8-256): 3.56e-60: 193: 29.64
+	Hs
		129536 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR3_HUMAN (5-208): 7.66e-50: 171: 29.03
+	Hs
		129584 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR14_HUMAN (6-250): 1.94e-44: 153: 22.98
+	Mm
		838552 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		TNR3_MOUSE (14-195): 4.66e-44: 156: 27.90
+	Hs
		129526 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR16_HUMAN (26-198): 9.45e-37: 136: 23.73
+	Mm
		192587 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09
+	Hs
		129538 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR4_HUMAN (8-234): 5.63e-37: 133: 20.71
+	Hs
		129553 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR9_HUMAN (38-266): 4.57e-34: 125: 20.90
+	Hs
		591320 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		TNR1B_HUMAN (12-234): 1.42e-53: 181: 30.26
+	Hs
		129533 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		CD27_HUMAN (5-122): 1.98e-24: 100: 26.45
+	Mm
		838553 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR3_MOUSE (14-195): 4.66e-44: 156: 27.90
+	Hs
		129599 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR19_HUMAN (7-142): 1.42e-19: 89.5: 18.62
+	Hs
		129534 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR8_HUMAN (43-274): 2.5e-18: 86.5: 16.80
+	Mm
		812913 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR4_MOUSE (25-234): 1.46e-42: 148: 22.86
+	Hs
		584394 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		TNR1A_HUMAN (23-251): 1.84e-39: 144: 20.59
+	Hs
		436620 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		TNR16_HUMAN (26-198): 9.45e-37: 136: 23.73
+	Mm
		591448 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR9_MOUSE (35-262): 7.48e-33: 122: 20.08