HitPredict

Interactor 1: TRAF5 (O00463)
TNF receptor-associated factor 5 (RING finger protein 84)
Gene: TRAF5

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.731

Property	Details
Experiments	36045679, 26221961, 27348524, 31390091, 31806368, 20161788
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0051091 - positive regulation of DNA-binding transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 557 Hs			1 540
+	Hs
		1024700 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		936210 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Hs
		1020764 TRAF2_HUMAN (28-554): 1.19e-102: 320: 31.66		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		1141429 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Hs
		1190136 TRAF6_HUMAN (21-551): 1.31e-81: 266: 22.02		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		1023708 TRAF1_HUMAN (161-552): 9.66e-75: 245: 30.00		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		584997 RO52_HUMAN (32-468): 2.83e-73: 243: 11.19		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		761831 TRAF2_MOUSE (28-554): 5.26e-102: 318: 33.46		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Mm
		1112346 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		SC24A_MOUSE (93-490): 4.12e-17: 87.2: 16.71
+	Hs
		1190083 TRIM7_HUMAN (18-469): 2.35e-60: 209: 11.48		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		101444 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		F8VPR5_MOUSE (82-395): 1.45e-11: 69.8: 14.24
+	Mm
		936265 TRAF6_MOUSE (21-551): 2.76e-83: 271: 22.20		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Hs
		1052694 TRI25_HUMAN (38-387): 1.04e-43: 166: 15.43		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		1112453 Q3UCL2_MOUSE (35-468): 5.5e-73: 241: 11.67		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Hs
		1190082 TRI31_HUMAN (34-365): 4.69e-41: 155: 16.42		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		585039 RO52_HUMAN (32-468): 2.83e-73: 243: 11.19		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Hs
		537122 TRI27_HUMAN (32-469): 5.05e-69: 233: 10.97		MAGL2_HUMAN (48-539): 3.46e-09: 61.8: 10.14
+	Hs
		1223389 TRI22_HUMAN (38-468): 2.92e-62: 214: 10.70		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Hs
		1052695 TRI25_HUMAN (38-387): 1.04e-43: 166: 15.43		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Hs
		1052742 TRI25_HUMAN (38-387): 1.04e-43: 166: 15.43		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58