HitPredict

Interactor 1: TRAF5 (O00463)
TNF receptor-associated factor 5 (RING finger protein 84)
Gene: TRAF5

Interactor 2: TNR14 (Q92956)
Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
Gene: TNFRSF14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	9153189, 9162022, 10799510
Identification Methods	two hybrid, affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 557 Hs			1 283
+	Mm
		936208 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		TNR14_MOUSE (1-256): 1.12e-77: 238: 44.11
+	Mm
		192584 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		TNR11_MOUSE (22-225): 1.45e-53: 185: 25.00
+	Hs
		129607 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR11_HUMAN (38-224): 3.77e-49: 173: 26.80
+	Hs
		129532 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR5_HUMAN (31-225): 3.22e-51: 171: 28.28
+	Hs
		129536 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR3_HUMAN (31-211): 3.54e-48: 167: 28.72
+	Mm
		838552 TRAF5_MOUSE (1-557): 4.13e-146: 434: 79.57		TNR3_MOUSE (31-207): 2.66e-42: 151: 28.65
+	Hs
		584394 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		TNR1A_HUMAN (25-277): 1.97e-62: 205: 19.39
+	Mm
		192587 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR11_MOUSE (22-225): 1.45e-53: 185: 25.00
+	Mm
		648958 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR5_MOUSE (22-225): 2.69e-54: 179: 29.13
+	Hs
		129533 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		CD27_HUMAN (23-266): 2.68e-29: 113: 14.84
+	Hs
		129538 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR4_HUMAN (42-204): 3.08e-25: 102: 25.15
+	Hs
		591320 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		TNR1B_HUMAN (30-214): 2e-49: 171: 26.98
+	Hs
		129553 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR9_HUMAN (48-208): 1.68e-23: 98: 25.31
+	Hs
		129599 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR19_HUMAN (23-146): 9.87e-19: 87.2: 22.73
+	Mm
		838553 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR3_MOUSE (31-207): 2.66e-42: 151: 28.65
+	Hs
		129534 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR8_HUMAN (59-176): 4.18e-13: 71: 22.03
+	Hs
		129526 TRAF5_HUMAN (1-557): 1.31e-149: 443: 100.00		TNR16_HUMAN (24-125): 1.13e-12: 69.5: 28.70
+	Mm
		812913 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR4_MOUSE (41-213): 3.68e-31: 118: 27.01
+	Mm
		591448 TRAF3_MOUSE (2-556): 1.12e-124: 379: 41.09		TNR9_MOUSE (54-210): 3.9e-24: 99: 26.58
+	Hs
		436620 TRAF3_HUMAN (4-556): 6.49e-122: 372: 40.99		TNR16_HUMAN (24-125): 1.13e-12: 69.5: 28.70