HitPredict

Interactor 1: ASPP1 (Q96KQ4)
Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
Gene: PPP1R13B

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1090 Hs			1 1116
+	Hs
		1043754 ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		125654 ASPP1_HUMAN (1-1090): 1.25e-150: 479: 100.00		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		1043731 ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		125441 ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		161388 MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		1167388 DOT1L_HUMAN (94-844): 1.19e-72: 266: 16.97		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		1199790 Q9H4D1_HUMAN (561-1075): 1.25e-59: 221: 13.12		MAGI2_HUMAN (4-650): 6.29e-50: 195: 11.18
+	Hs
		883551 RIPK4_HUMAN (623-1075): 3.32e-58: 218: 14.29		MAGI2_HUMAN (4-650): 6.29e-50: 195: 11.18
+	Dm
		1376443 Q9W2J2_DROME (125-1085): 1.06e-64: 240: 27.72		Q9W2L2_DROME (4-633): 7.38e-42: 169: 11.16
+	Hs
		167047 ANR28_HUMAN (709-1086): 2.22e-47: 186: 12.88		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		1260094 IASPP_HUMAN (336-1089): 6.59e-57: 214: 22.46		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		1239521 ANR52_HUMAN (751-1080): 6.18e-45: 178: 14.04		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		167015 ANR28_HUMAN (709-1086): 2.22e-47: 186: 12.88		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		1167443 ANR50_HUMAN (872-1088): 2.19e-39: 161: 17.70		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Dm
		113976 M9PB30_DROME (414-891): 2.79e-15: 83.6: 11.22		M9PB30_DROME (75-1108): 1.56e-58: 224: 10.96
+	Hs
		125583 ANR44_HUMAN (750-1058): 2.63e-46: 183: 14.11		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		556716 ANK1_HUMAN (817-1090): 2.13e-47: 187: 14.43		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Hs
		276214 PSD10_HUMAN (786-961): 3.4e-22: 98.4: 14.77		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		166985 ANR28_HUMAN (709-1086): 2.22e-47: 186: 12.88		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Hs
		125054 PSD10_HUMAN (786-961): 3.4e-22: 98.4: 14.77		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51