HitPredict

Interactor 1: EGLN2 (Q96KS0)
Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)
Gene: EGLN2

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.785

Property	Details
Experiments	17353276, 23275444
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	2OG-FeII_Oxy_3~HIF-1
Common GO terms	GO:0001666 - response to hypoxia GO:0005654 - nucleoplasm GO:0071456 - cellular response to hypoxia
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 870
+	Hs
		1306535 EGLN1_HUMAN (122-405): 2.5e-166: 474: 57.75		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1085645 EGLN2_HUMAN (1-407): 0: 719: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1306537 EGLN3_HUMAN (175-393): 8.24e-138: 395: 60.46		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Mm
		1142405 EGLN2_MOUSE (1-407): 0: 689: 86.94		HIF1A_MOUSE (3-787): 0: 549: 43.60
+	Hs
		649144 EGLN2_HUMAN (1-407): 0: 719: 100.00		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		1085668 EGLN1_HUMAN (122-405): 2.5e-166: 474: 57.75		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Mm
		1142406 EGLN1_MOUSE (111-407): 6.66e-167: 475: 56.33		HIF1A_MOUSE (3-787): 0: 549: 43.60
+	Hs
		1085680 EGLN3_HUMAN (175-393): 8.24e-138: 395: 60.46		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		87731 EGLN3_HUMAN (175-393): 8.24e-138: 395: 60.46		D0VY79_HUMAN (3-868): 0: 553: 42.32
+	Mm
		1142404 EGLN3_MOUSE (175-393): 6.6e-139: 397: 60.91		HIF1A_MOUSE (3-787): 0: 549: 43.60
+	Hs
		649156 EGLN1_HUMAN (122-405): 2.5e-166: 474: 57.75		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		649159 EGLN3_HUMAN (175-393): 8.24e-138: 395: 60.46		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		728960 EGLN3_HUMAN (175-393): 8.24e-138: 395: 60.46		AHR_HUMAN (5-706): 9.13e-121: 387: 16.46
+	Hs
		1075392 EGLN3_HUMAN (175-393): 8.24e-138: 395: 60.46		NCOA2_HUMAN (6-564): 4.76e-97: 334: 18.53