HitPredict

Interactor 1: PGRP3 (Q96LB9)
Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)
Gene: PGLYRP3

Interactor 2: PGRP3 (Q96LB9)
Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)
Gene: PGLYRP3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

The method score is based on:

Property	Details
Experiments	15140887, 16354652
Identification Methods	x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Amidase_2~Amidase_2
Common GO terms	GO:0005576 - extracellular region GO:0008270 - zinc ion binding GO:0008745 - N-acetylmuramoyl-L-alanine amidase activity GO:0009253 - peptidoglycan catabolic process GO:0016019 - peptidoglycan immune receptor activity and 12 others more... GO:0016020 - membrane GO:0016045 - detection of bacterium GO:0031640 - killing of cells of another organism GO:0032689 - negative regulation of type II interferon production GO:0032827 - negative regulation of natural killer cell differentiation involved in immune response GO:0032991 - protein-containing complex GO:0042834 - peptidoglycan binding GO:0045087 - innate immune response GO:0046982 - protein heterodimerization activity GO:0050830 - defense response to Gram-positive bacterium GO:0051701 - biological process involved in interaction with host GO:0061844 - antimicrobial humoral immune response mediated by antimicrobial peptide
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	341
Hs

1	341

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Last updated: 15 Jul 2024