HitPredict

Interactor 1: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Interactor 2: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.871

The method score is based on:

Property Details
Experiments 30641048, 30612879, 23582325, 24630722
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, electron microscopy
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_6~LRR_6, NACHT~NACHT, NACHT~NLRC4_HD2, NACHT~NOD2_WH, NLRC4_HD2~NOD2_WH, PYRIN~PYRIN
Common GO terms GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002674 - negative regulation of acute inflammatory response
GO:0002830 - positive regulation of type 2 immune response
GO:0005524 - ATP binding
and 49 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Last updated: 15 Jul 2024