HitPredict

Interactor 1: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 30653357, 32003754, 34407203, 34341353, 30182366, 32435622, 34431717, 34825365, 33460751, 30612879, 19158675, 15030775, 12615073, 19337385, 21575908, 24803432, 16037825, 11786556, 24630722, 28229991 and 3 others

more...
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid, fluorescence microscopy, fluorescence polarization spectroscopy, surface plasmon resonance, anti bait coimmunoprecipitation, electron microscopy
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PYRIN~PYRIN
Common GO terms GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 18 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1036
Hs

1 195
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024