HitPredict

Interactor 1: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Interactor 2: FAF1 (Q9UNN5)
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)
Gene: FAF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	17046979
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1036 Hs			1 650
+	Hs
		1263228 NALP7_HUMAN (10-1035): 0: 610: 30.38		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		1202840 NAL10_HUMAN (2-623): 8.63e-152: 467: 34.78		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		886433 NAL12_HUMAN (788-1036): 1.62e-36: 151: 39.76		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		1347597 NALP2_HUMAN (844-1029): 8.96e-14: 78.2: 31.18		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		1200101 NLRX1_HUMAN (826-1021): 4.41e-13: 75.9: 23.23		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		1318403 NALP2_HUMAN (844-1029): 8.96e-14: 78.2: 31.18		UBXN6_HUMAN (395-645): 7.43e-34: 136: 15.73