HitPredict

Interactor 1: MEIS1 (O00470)
Homeobox protein Meis1
Gene: MEIS1

Interactor 2: TLX3 (O43711)
T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)
Gene: TLX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	20211142
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045665 - negative regulation of neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 291
+	Mm
		857948 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		PDX1_MOUSE (63-246): 3.08e-41: 145: 26.56
+	Mm
		1141920 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		Q9QX99_MOUSE (2-290): 4.68e-37: 136: 52.94
+	Hs
		129968 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30
+	Mm
		446924 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXA5_MOUSE (30-237): 8.43e-37: 133: 21.21
+	Mm
		678762 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXA2_MOUSE (50-235): 3.31e-35: 131: 25.13
+	Mm
		488048 MEIS1_MOUSE (1-390): 7.9e-139: 402: 99.74		HXB4_MOUSE (28-226): 6.88e-35: 128: 23.12
+	Hs
		129960 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		TLX2_HUMAN (11-290): 4.67e-32: 121: 58.87
+	Hs
		129972 MEIS1_HUMAN (1-390): 7.65e-139: 402: 100.00		EMX2_HUMAN (9-239): 1.06e-29: 114: 27.78
+	Hs
		154467 MEIS2_HUMAN (1-385): 2.83e-116: 348: 80.81		TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30
+	Mm
		956309 MEIS2_MOUSE (1-385): 7e-117: 350: 80.81		EMX1_MOUSE (9-240): 1.33e-32: 122: 24.90
+	Dm
		221160 HTH_DROME (1-389): 3.2e-87: 274: 47.00		UBX_DROME (25-230): 3.49e-31: 121: 22.28
+	Hs
		174014 PKNX1_HUMAN (13-379): 5.44e-82: 259: 35.08		SHOX_HUMAN (93-257): 3.49e-34: 127: 18.18
+	Mm
		447608 PKNX2_MOUSE (1-376): 1.74e-80: 256: 35.47		HXA6_MOUSE (20-244): 9.52e-31: 116: 17.70
+	Hs
		679069 PBX3_HUMAN (6-390): 8.78e-52: 180: 15.71		TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30
+	Mm
		192602 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXB5_MOUSE (45-241): 3.99e-32: 121: 26.90
+	Hs
		446878 PBX4_HUMAN (43-363): 2.15e-52: 180: 16.81		HXD4_HUMAN (17-257): 9.6e-32: 120: 19.92
+	Hs
		447287 PBX4_HUMAN (43-363): 2.15e-52: 180: 16.81		HXB5_HUMAN (45-241): 8.41e-32: 120: 26.90
+	Mm
		192603 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXA6_MOUSE (20-244): 9.52e-31: 116: 17.70
+	Mm
		192606 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXD4_MOUSE (17-252): 3.37e-29: 113: 21.61
+	Mm
		192607 PBX3_MOUSE (6-390): 1.25e-51: 180: 15.71		HXC6_MOUSE (34-224): 1.75e-29: 113: 21.13