HitPredict

Interactor 1: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Interactor 2: TXNIP (Q9H3M7)
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Gene: TXNIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	38270169
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 975 Hs			1 391
+	Hs
		1285052 NED4L_HUMAN (1-975): 0: 1033: 100.00		ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35
+	Hs
		1252808 NED4L_HUMAN (1-975): 0: 1033: 100.00		ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85
+	Hs
		1241907 NED4L_HUMAN (1-975): 0: 1033: 100.00		ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99
+	Hs
		1234602 NED4L_HUMAN (1-975): 0: 1033: 100.00		ARRD1_HUMAN (4-380): 4.63e-70: 228: 20.05
+	Hs
		1327911 WWP1_HUMAN (1-972): 0: 781: 33.13		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Hs
		1285070 WWP1_HUMAN (1-972): 0: 781: 33.13		ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35
+	Hs
		1252814 WWP1_HUMAN (1-972): 0: 781: 33.13		ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85
+	Hs
		1241917 WWP1_HUMAN (1-972): 0: 781: 33.13		ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99
+	Dm
		115614 M9PFK2_DROME (6-975): 0: 846: 45.79		Q9VI00_DROME (8-379): 1.03e-93: 289: 21.91
+	Dm
		1367624 NEDD4_DROME (6-975): 0: 845: 46.15		Q9VI00_DROME (8-379): 1.03e-93: 289: 21.91
+	Dm
		115611 M9PFK2_DROME (6-975): 0: 846: 45.79		Q8SYU5_DROME (8-380): 5.97e-89: 278: 16.75
+	Dm
		1249345 NEDD4_DROME (6-975): 0: 845: 46.15		Q8SYU5_DROME (8-380): 5.97e-89: 278: 16.75
+	Dm
		115613 M9PFK2_DROME (6-975): 0: 846: 45.79		Q9VHZ7_DROME (10-301): 2.68e-77: 249: 22.15
+	Dm
		1367606 NEDD4_DROME (6-975): 0: 845: 46.15		Q9VHZ7_DROME (10-301): 2.68e-77: 249: 22.15
+	Dm
		115612 M9PFK2_DROME (6-975): 0: 846: 45.79		Q9VGU4_DROME (9-307): 1.81e-68: 226: 17.95
+	Dm
		1366431 NEDD4_DROME (6-975): 0: 845: 46.15		Q9VGU4_DROME (9-307): 1.81e-68: 226: 17.95
+	Hs
		1234607 WWP1_HUMAN (1-972): 0: 781: 33.13		ARRD1_HUMAN (4-380): 4.63e-70: 228: 20.05
+	Hs
		1234600 ITCH_HUMAN (9-972): 0: 772: 33.16		ARRD1_HUMAN (4-380): 4.63e-70: 228: 20.05
+	Hs
		686035 ITCH_HUMAN (9-972): 0: 772: 33.16		ARRB2_HUMAN (15-323): 2.03e-60: 202: 12.18
+	Hs
		827260 ITCH_HUMAN (9-972): 0: 772: 33.16		ARRB1_HUMAN (25-358): 2.59e-56: 191: 12.95