HitPredict

Interactor 1: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Interactor 2: SGK2 (Q9HBY8)
Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2)
Gene: SGK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0015459 - potassium channel regulator activity GO:0017080 - sodium channel regulator activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 975 Hs			1 367
+	Hs
		117024 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK1_HUMAN (3-365): 9.63e-154: 441: 68.73
+	Hs
		1299664 NED4L_HUMAN (1-975): 0: 1033: 100.00		AKT3_HUMAN (1-359): 6.48e-151: 436: 47.66
+	Hs
		681988 NED4L_HUMAN (1-975): 0: 1033: 100.00		AKT1_HUMAN (6-359): 3.45e-151: 436: 47.62
+	Hs
		1285839 NED4L_HUMAN (1-975): 0: 1033: 100.00		SGK3_HUMAN (9-364): 7.87e-146: 423: 67.69
+	Hs
		1299657 NED4L_HUMAN (1-975): 0: 1033: 100.00		KS6B2_HUMAN (27-361): 4.56e-146: 423: 45.29
+	Mm
		1208292 NED4L_MOUSE (17-975): 0: 1014: 98.02		SGK1_MOUSE (20-365): 2.41e-153: 440: 71.92
+	Xl
		1151478 Q6GMD5_XENLA (7-975): 0: 1003: 89.69		SGK1A_XENLA (1-365): 3.11e-155: 445: 67.38
+	Mm
		93288 E9PXB7_MOUSE (122-975): 0: 863: 95.79		SGK1_MOUSE (20-365): 2.41e-153: 440: 71.92
+	Hs
		1285838 ITCH_HUMAN (9-972): 0: 772: 33.16		SGK3_HUMAN (9-364): 7.87e-146: 423: 67.69
+	Hs
		808277 NEDD4_HUMAN (94-975): 0: 724: 49.78		SGK2_HUMAN (1-367): 5.99e-163: 462: 100.00
+	Hs
		116984 NEDD4_HUMAN (94-975): 0: 724: 49.78		SGK1_HUMAN (3-365): 9.63e-154: 441: 68.73
+	Hs
		681731 NEDD4_HUMAN (94-975): 0: 724: 49.78		AKT1_HUMAN (6-359): 3.45e-151: 436: 47.62
+	Hs
		808324 NEDD4_HUMAN (94-975): 0: 724: 49.78		AKT3_HUMAN (1-359): 6.48e-151: 436: 47.66
+	Hs
		616684 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6B1_HUMAN (4-361): 3.11e-145: 422: 42.15
+	Hs
		808054 NEDD4_HUMAN (94-975): 0: 724: 49.78		KS6A3_HUMAN (25-335): 1.1e-104: 325: 25.47
+	Hs
		784035 HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26		KPCI_HUMAN (34-340): 2.85e-99: 307: 46.23
+	Hs
		983863 HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26		KPCZ_HUMAN (34-357): 1.99e-96: 300: 45.21
+	Hs
		784093 SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71		KPCI_HUMAN (34-340): 2.85e-99: 307: 46.23