HitPredict

Interactor 1: LMTK3 (Q96Q04)
Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3)
Gene: LMTK3

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1460 Hs			1 1697
+	Hs
		1168427 LMTK1_HUMAN (14-1439): 0: 685: 30.30		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		1078847 LMTK1_HUMAN (14-1439): 0: 685: 30.30		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		601605 FGFR2_HUMAN (2-471): 1.02e-125: 413: 21.64		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		508233 FGFR1_HUMAN (2-458): 1.89e-124: 410: 23.51		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		508022 FGFR1_HUMAN (2-458): 1.89e-124: 410: 23.51		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		787962 LMTK3_HUMAN (1-1460): 0: 925: 100.00		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Hs
		787931 LMTK1_HUMAN (14-1439): 0: 685: 30.30		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Mm
		949272 TNIK_MOUSE (113-1160): 4.13e-140: 466: 12.40		TRIO_MOUSE (205-1561): 8.34e-74: 276: 10.98
+	Hs
		337577 ABL1_HUMAN (65-993): 2.2e-127: 426: 17.10		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		337383 ABL1_HUMAN (65-993): 2.2e-127: 426: 17.10		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Mm
		949375 TNIK_MOUSE (113-1160): 4.13e-140: 466: 12.40		NGEF_MOUSE (1200-1461): 1.49e-19: 97.4: 28.94
+	Mm
		57836 TNIK_MOUSE (113-1160): 4.13e-140: 466: 12.40		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Hs
		167058 ABL1_HUMAN (65-993): 2.2e-127: 426: 17.10		ARHGB_HUMAN (1207-1441): 1.17e-20: 101: 30.08
+	Ce
		371330 ABL1_CAEEL (30-974): 1.41e-126: 426: 15.16		Q9BIF4_CAEEL (106-331): 1.35e-17: 91.4: 22.91
+	Hs
		508143 FGFR1_HUMAN (2-458): 1.89e-124: 410: 23.51		ARHGQ_HUMAN (1202-1462): 1.19e-21: 104: 27.57
+	Hs
		337333 ABL1_HUMAN (65-993): 2.2e-127: 426: 17.10		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		548706 FAK2_HUMAN (4-594): 1.7e-125: 418: 21.30		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Mm
		57841 M3K9_MOUSE (72-1081): 2.56e-130: 433: 18.40		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Hs
		507829 FGFR1_HUMAN (2-458): 1.89e-124: 410: 23.51		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		508045 FGFR1_HUMAN (2-458): 1.89e-124: 410: 23.51		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26