HitPredict

Interactor 1: SMG1 (Q96Q15)
Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)
Gene: SMG1

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20371770
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006281 - DNA repair
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 3661 Hs			1 456
+	Hs
		1300093 SMG1_HUMAN (1-3661): 0: 5538: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Dm
		1366582 TOR_DROME (1605-2520): 3.73e-179: 618: 21.03		RUVB1_DROME (1-455): 0: 660: 79.56
+	Dm
		1358868 TOR_DROME (1605-2520): 3.73e-179: 618: 21.03		RUVB2_DROME (5-455): 0: 640: 45.25
+	Sc
		715255 TOR1_YEAST (1605-2520): 3.59e-175: 606: 20.38		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Mm
		888083 TRRAP_MOUSE (1613-2498): 2.2e-131: 467: 13.36		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		1377044 TRRAP_HUMAN (1613-2498): 7e-125: 447: 13.14		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Sp
		1319465 TRA1_SCHPO (1656-2489): 7.62e-126: 450: 14.17		RUVB1_SCHPO (1-456): 0: 671: 69.96
+	Dm
		1211950 TRA1_DROME (1613-2498): 5.34e-128: 457: 14.36		RUVB1_DROME (1-455): 0: 660: 79.56
+	Hs
		1376985 TRRAP_HUMAN (1613-2498): 7e-125: 447: 13.14		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sp
		294006 TRA1_SCHPO (1656-2489): 7.62e-126: 450: 14.17		RUVB2_SCHPO (1-455): 0: 639: 42.45
+	Hs
		944486 PRKDC_HUMAN (1985-2462): 7.37e-99: 361: 20.61		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Sc
		755452 TRA1_YEAST (1731-2470): 4.08e-113: 408: 11.44		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Hs
		1031646 ATM_HUMAN (1965-2507): 1.26e-95: 351: 23.05		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1038195 ATR_HUMAN (1920-2466): 1.45e-92: 340: 22.16		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		944485 PRKDC_HUMAN (1985-2462): 7.37e-99: 361: 20.61		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		744167 ATR_YEAST (2049-2467): 2.16e-78: 293: 25.62		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		744182 ATR_YEAST (2049-2467): 2.16e-78: 293: 25.62		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Hs
		787606 MTOR_HUMAN (1604-1771): 4.69e-19: 98: 11.30		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		787605 MTOR_HUMAN (1604-1771): 4.69e-19: 98: 11.30		RUVB2_HUMAN (2-455): 0: 651: 42.76