HitPredict

Interactor 1: NR1H4 (Q96RI1)
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
Gene: NR1H4

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16219912
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0046965 - nuclear retinoid X receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 486 Hs			1 2514
+	Hs
		370824 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		587211 RXRA_HUMAN (11-485): 4.19e-119: 358: 20.78		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		818890 RXRG_HUMAN (11-484): 2.01e-117: 354: 20.78		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1025275 NR1H3_HUMAN (60-486): 1.64e-112: 341: 34.57		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		874405 NR1H2_HUMAN (44-486): 5.33e-109: 332: 30.19		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		261568 NR1H4_HUMAN (1-486): 6.66e-163: 471: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261369 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261399 RXRA_HUMAN (11-485): 4.19e-119: 358: 20.78		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261493 NR1H3_HUMAN (60-486): 1.64e-112: 341: 34.57		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261450 NR1H2_HUMAN (44-486): 5.33e-109: 332: 30.19		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Dm
		115933 ECR_DROME (88-486): 2.9e-106: 337: 33.26		M9PGZ8_DROME (113-505): 6.74e-62: 238: 36.96
+	Hs
		370417 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		TARA_HUMAN (40-1577): 3.75e-52: 206: 9.68
+	Mm
		1206787 NR1H3_MOUSE (70-486): 1.03e-111: 339: 35.15		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Hs
		370728 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		370263 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		370251 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		370040 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93
+	Hs
		370105 ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61
+	Hs
		490111 COT1_HUMAN (37-483): 1.43e-106: 325: 21.41		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Dm
		558435 7UP1_DROME (10-483): 2.46e-103: 321: 20.65		Q86BH2_DROME (1390-2499): 5.45e-13: 77.3: 8.44