HitPredict

Interactor 1: FER3L (Q96RJ6)
Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist)
Gene: FERD3L

Interactor 2: HTF4 (Q99081)
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: TCF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	32296183, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 682
+	Hs
		551571 TFE2_HUMAN (2-166): 1.28e-29: 115: 18.71		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Hs
		551256 ITF2_HUMAN (1-164): 8.46e-27: 107: 17.13		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Hs
		616615 MYF6_HUMAN (16-164): 2.17e-28: 106: 22.82		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Mm
		1141282 ITF2_MOUSE (1-164): 6.15e-27: 107: 18.38		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Hs
		551254 FER3L_HUMAN (1-166): 2.03e-42: 140: 100.00		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Mm
		1141279 ITF2_MOUSE (1-164): 6.15e-27: 107: 18.38		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Hs
		551569 FER3L_HUMAN (1-166): 2.03e-42: 140: 100.00		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		551056 TFE2_HUMAN (2-166): 1.28e-29: 115: 18.71		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551055 ITF2_HUMAN (1-164): 8.46e-27: 107: 17.13		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551069 MYF6_HUMAN (16-164): 2.17e-28: 106: 22.82		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Mm
		550241 FER3L_MOUSE (1-165): 9.27e-42: 139: 76.65		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Hs
		551462 TFE2_HUMAN (2-166): 1.28e-29: 115: 18.71		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		526739 MYF5_HUMAN (29-163): 1.45e-28: 107: 25.53		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		551472 MYF6_HUMAN (16-164): 2.17e-28: 106: 22.82		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Mm
		485935 MYOD1_MOUSE (8-166): 5.53e-30: 113: 25.79		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		550186 ATOH1_MOUSE (5-164): 1.38e-27: 107: 23.43		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		550204 ITF2_MOUSE (1-164): 6.15e-27: 107: 18.38		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		823150 ATOH1_MOUSE (5-164): 1.38e-27: 107: 23.43		Q91YV0_MOUSE (193-682): 0: 598: 64.41
+	Ce
		106832 HLH6_CAEEL (15-159): 3.78e-29: 109: 20.53		HLH2_CAEEL (530-650): 8.15e-31: 126: 42.86