HitPredict

Interactor 1: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Interactor 2: ZBT18 (Q99592)
Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)
Gene: ZBTB18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2517 Hs			1 522
+	Hs
		200301 CIC_HUMAN (1-2517): 0: 961: 100.00		ZBT43_HUMAN (1-485): 4.34e-93: 293: 26.01
+	Hs
		1294994 CIC_HUMAN (1-2517): 0: 961: 100.00		HIC2_HUMAN (1-504): 2.56e-86: 280: 21.27
+	Hs
		1241830 CIC_HUMAN (1-2517): 0: 961: 100.00		ZBT44_HUMAN (8-491): 2.1e-79: 260: 18.63
+	Hs
		1024298 CIC_HUMAN (1-2517): 0: 961: 100.00		ZBT17_HUMAN (80-367): 5.88e-32: 132: 7.86
+	Hs
		312085 CIC_HUMAN (1-2517): 0: 961: 100.00		ZBT7A_HUMAN (439-522): 1.75e-29: 124: 27.06
+	Hs
		196656 CIC_HUMAN (1-2517): 0: 961: 100.00		ZBT24_HUMAN (205-396): 6.62e-21: 98.3: 17.10
+	Hs
		1300976 CIC_HUMAN (1-2517): 0: 961: 100.00		ZN629_HUMAN (121-394): 1.25e-10: 66.3: 10.32
+	Hs
		727911 SOX6_HUMAN (887-1289): 5.1e-35: 148: 16.28		ZN184_HUMAN (38-462): 2.55e-113: 354: 11.68
+	Hs
		818499 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		ZNF71_HUMAN (188-522): 1.23e-89: 285: 18.10
+	Hs
		1331994 LEF1_HUMAN (929-1200): 1.93e-32: 134: 21.82		ZBTB3_HUMAN (1-497): 3.36e-111: 343: 36.33
+	Mm
		1145315 NCOR2_MOUSE (308-2034): 8.87e-14: 80.2: 8.91		ZBT7B_MOUSE (1-507): 7.67e-86: 277: 22.84
+	Hs
		312035 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		ZBT7A_HUMAN (439-522): 1.75e-29: 124: 27.06
+	Hs
		166160 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		ZBTB5_HUMAN (1-174): 1.62e-21: 100: 34.09
+	Hs
		818150 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		ZN787_HUMAN (372-492): 6.74e-17: 84.3: 42.15
+	Mm
		292474 SOX9_MOUSE (1031-1201): 4.76e-25: 114: 23.08		ZBT7A_MOUSE (439-522): 9.36e-30: 124: 27.06
+	Hs
		312036 SOX9_HUMAN (1031-1201): 1.04e-24: 112: 23.08		ZBT7A_HUMAN (439-522): 1.75e-29: 124: 27.06
+	Hs
		312107 NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06		ZBT7A_HUMAN (439-522): 1.75e-29: 124: 27.06
+	Hs
		1304783 TARA_HUMAN (523-2026): 3.76e-17: 91.1: 11.33		ZBT18_HUMAN (438-521): 3.04e-22: 101: 21.65
+	Hs
		166193 NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06		ZBTB5_HUMAN (1-174): 1.62e-21: 100: 34.09
+	Hs
		1304807 PRC2C_HUMAN (310-2236): 1.98e-13: 79.1: 9.20		ZBT18_HUMAN (438-521): 3.04e-22: 101: 21.65