HitPredict

Interactor 1: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Interactor 2: NKX24 (Q9H2Z4)
Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D)
Gene: NKX2-4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29844126
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2517 Hs			1 354
+	Hs
		858119 CIC_HUMAN (1-2517): 0: 961: 100.00		NKX25_HUMAN (50-339): 2.04e-38: 141: 34.77
+	Hs
		641534 CIC_HUMAN (1-2517): 0: 961: 100.00		PAX6_HUMAN (13-348): 5.44e-34: 131: 15.77
+	Hs
		679158 CIC_HUMAN (1-2517): 0: 961: 100.00		TLX1_HUMAN (160-279): 4.68e-33: 127: 28.68
+	Hs
		238117 CIC_HUMAN (1-2517): 0: 961: 100.00		LMX1B_HUMAN (147-348): 1.01e-30: 122: 15.61
+	Hs
		1300914 CIC_HUMAN (1-2517): 0: 961: 100.00		PITX2_HUMAN (150-342): 5.91e-31: 121: 18.14
+	Hs
		567874 CIC_HUMAN (1-2517): 0: 961: 100.00		HXB9_HUMAN (12-254): 4.3e-31: 119: 21.51
+	Hs
		839810 CIC_HUMAN (1-2517): 0: 961: 100.00		LHX2_HUMAN (98-321): 2.96e-28: 115: 12.00
+	Hs
		1199924 CIC_HUMAN (1-2517): 0: 961: 100.00		ZFHX4_HUMAN (145-276): 6.21e-12: 69.3: 14.29
+	Hs
		213372 CIC_HUMAN (1-2517): 0: 961: 100.00		TLX2_HUMAN (189-262): 9.62e-11: 63.5: 47.30
+	Hs
		211942 CIC_HUMAN (1-2517): 0: 961: 100.00		TLX3_HUMAN (189-262): 6.99e-10: 61.2: 45.95
+	Hs
		641335 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		PAX6_HUMAN (13-348): 5.44e-34: 131: 15.77
+	Mm
		818684 SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44		PAX6_MOUSE (13-348): 5.44e-34: 131: 15.77
+	Hs
		818455 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		ALX4_HUMAN (18-349): 2.12e-31: 124: 15.62
+	Hs
		818493 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		LHX9_HUMAN (110-310): 2.5e-31: 123: 18.40
+	Hs
		567820 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		HXB9_HUMAN (12-254): 4.3e-31: 119: 21.51
+	Mm
		818775 SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44		Q9QX99_MOUSE (160-279): 1.57e-32: 125: 29.46
+	Mm
		192289 SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44		ALX4_MOUSE (16-349): 3.67e-29: 117: 17.75
+	Hs
		818205 SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05		ZFHX4_HUMAN (145-276): 6.21e-12: 69.3: 14.29
+	Mm
		1142007 Q60I23_MOUSE (1102-1308): 2.84e-56: 201: 27.40		NANOG_MOUSE (177-271): 6.06e-10: 61.6: 41.84
+	Mm
		818733 SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44		NANOG_MOUSE (177-271): 6.06e-10: 61.6: 41.84