HitPredict

Interactor 1: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Interactor 2: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	24981860, 26186194, 23749998, 33961781, 32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 788 Hs			1 502
+	Hs
		826339 MED15_HUMAN (1-788): 2.62e-102: 335: 100.00		CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69
+	Mm
		1246868 MED15_MOUSE (1-788): 3.75e-97: 321: 79.92		CDK8_MOUSE (1-502): 7.79e-153: 445: 76.49
+	Dm
		1373830 MED15_DROME (9-784): 1.39e-55: 206: 24.72		CDK8_DROME (1-413): 7.19e-138: 407: 77.24
+	Hs
		826323 CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24		CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69
+	Hs
		625528 TITIN_HUMAN (156-460): 5.01e-12: 72.4: 11.53		CDK2_HUMAN (17-345): 1.91e-130: 382: 36.04
+	Hs
		625532 CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24		CDK2_HUMAN (17-345): 1.91e-130: 382: 36.04
+	Rn
		926487 SYNJ1_RAT (141-669): 3.33e-12: 72.5: 10.59		MK01_RAT (21-382): 5.15e-122: 363: 28.53
+	Hs
		659014 TITIN_HUMAN (156-460): 5.01e-12: 72.4: 11.53		MK01_HUMAN (21-382): 7e-122: 362: 28.53
+	Hs
		659020 CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24		MK01_HUMAN (21-382): 7e-122: 362: 28.53
+	Rn
		974742 SYNJ1_RAT (141-669): 3.33e-12: 72.5: 10.59		CDK5_RAT (26-337): 9.68e-58: 195: 37.86