HitPredict

Interactor 1: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Interactor 2: MED23 (Q9ULK4)
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
Gene: MED23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	25281560, 24981860, 33961781, 14657022
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Med15~Med23
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II and 1 others more... GO:0070847 - core mediator complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 788 Hs			1 1368
+	Hs
		1296856 EP400_HUMAN (236-579): 1.3e-19: 97: 20.00		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Hs
		1270837 CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Dm
		1376344 MED15_DROME (9-784): 1.39e-55: 206: 24.72		MED23_DROME (1-1336): 0: 1744: 48.34