HitPredict

Interactor 1: WDR24 (Q96S15)
GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24)
Gene: WDR24

Interactor 2: SESN1 (Q9Y6P5)
Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26)
Gene: SESN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	25263562, 26449471
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016239 - positive regulation of macroautophagy GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 790 Hs			1 492
+	Hs
		885148 WDR24_HUMAN (1-790): 0: 594: 100.00		SESN3_HUMAN (8-492): 0: 850: 61.29
+	Hs
		885138 WDR24_HUMAN (1-790): 0: 594: 100.00		SESN2_HUMAN (22-492): 0: 767: 58.74
+	Hs
		1162319 WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31		SESN1_HUMAN (1-492): 0: 874: 100.00
+	Hs
		1347918 MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22		SESN1_HUMAN (1-492): 0: 874: 100.00
+	Hs
		885147 WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31		SESN3_HUMAN (8-492): 0: 850: 61.29
+	Hs
		885150 MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22		SESN3_HUMAN (8-492): 0: 850: 61.29
+	Hs
		885130 WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31		SESN2_HUMAN (22-492): 0: 767: 58.74
+	Hs
		885141 MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22		SESN2_HUMAN (22-492): 0: 767: 58.74
+	Hs
		885117 WDR5_HUMAN (1-102): 2.39e-12: 71: 14.42		SESN2_HUMAN (22-492): 0: 767: 58.74