HitPredict

Interactor 1: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.790

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification, protein kinase assay
Interaction Type	physical association, direct interaction, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 655 Hs			1 282
+	Hs
		964049 SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		516651 SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		942600 SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		942906 SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		942631 SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516460 SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		964081 SRPK3_HUMAN (29-654): 1.98e-99: 317: 38.95		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Sc
		694216 SKY1_YEAST (13-654): 1.12e-118: 372: 33.13		PUB1_YEAST (12-99): 1.78e-17: 83.7: 20.46
+	Hs
		833957 CLK2_HUMAN (484-653): 2.41e-63: 220: 29.07		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		834109 CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		833805 CLK1_HUMAN (436-654): 8.6e-61: 212: 23.45		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		833874 CLK2_HUMAN (484-653): 2.41e-63: 220: 29.07		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		625400 CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		834030 CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516416 CLK2_HUMAN (484-653): 2.41e-63: 220: 29.07		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		834033 CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516362 CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516417 CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		647984 MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Zm
		8045 A0A1D6EK73_MAIZE (414-654): 1.73e-55: 198: 13.77		A0A1D6PN12_MAIZE (12-248): 2.96e-17: 81.5: 27.85