HitPredict

Interactor 1: HMGN4 (O00479)
High mobility group nucleosome-binding domain-containing protein 4 (Non-histone chromosomal protein HMG-17-like 3) (Non-histone chromosomal protein)
Gene: HMGN4

Interactor 2: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28190768, 35013556
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 90 Hs			1 1014
+	Hs
		398809 HMGN2_HUMAN (1-90): 3.82e-21: 81: 86.67		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		130284 HMGN4_HUMAN (1-90): 1.56e-30: 104: 100.00		PARP2_HUMAN (514-1014): 0: 594: 41.72
+	Hs
		398963 HMGN2_HUMAN (1-90): 3.82e-21: 81: 86.67		PARP2_HUMAN (514-1014): 0: 594: 41.72
+	Hs
		130257 HMGN4_HUMAN (1-90): 1.56e-30: 104: 100.00		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71