HitPredict

Interactor 1: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Interactor 2: MAD3 (Q9BW11)
Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx)
Gene: MXD3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	28514442, 33961781, 9184233
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1273 Hs			1 206
+	Hs
		840222 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MXI1_HUMAN (7-180): 1.16e-50: 165: 50.27
+	Mm
		840232 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		MXI1_MOUSE (7-185): 2.11e-48: 159: 50.79
+	Hs
		983439 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MAD1_HUMAN (7-180): 2.38e-47: 156: 48.28
+	Mm
		840195 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		MAD1_MOUSE (7-171): 3.32e-47: 156: 50.30
+	Mm
		1141057 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		Q91VN7_MOUSE (20-181): 3.25e-43: 145: 47.53
+	Mm
		139906 SIN3A_MOUSE (1-1273): 0: 1542: 98.04		MNT_MOUSE (39-178): 4.47e-38: 140: 31.33
+	Hs
		1302431 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MNT_HUMAN (39-178): 2.98e-35: 132: 30.67
+	Hs
		347665 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MYC_HUMAN (26-140): 2.35e-34: 128: 25.00
+	Hs
		898177 SIN3A_HUMAN (1-1273): 0: 1545: 100.00		MAX_HUMAN (54-164): 5.61e-15: 70.9: 20.72
+	Mm
		840233 SIN3B_MOUSE (110-1273): 0: 1237: 51.12		MXI1_MOUSE (7-185): 2.11e-48: 159: 50.79
+	Mm
		840196 SIN3B_MOUSE (110-1273): 0: 1237: 51.12		MAD1_MOUSE (7-171): 3.32e-47: 156: 50.30
+	Mm
		139907 SIN3B_MOUSE (110-1273): 0: 1237: 51.12		MNT_MOUSE (39-178): 4.47e-38: 140: 31.33
+	Ce
		60879 SIN3_CAEEL (60-1079): 0: 716: 19.90		MXL3_CAEEL (55-127): 2.51e-20: 87.1: 31.51
+	Dm
		1137188 Q5U0Y0_DROME (35-539): 2.36e-50: 198: 21.88		X2JDM5_DROME (29-155): 2.07e-31: 122: 29.23
+	Rn
		61827 A6K9M6_RAT (298-557): 2.13e-28: 118: 19.85		MYC_RAT (26-140): 7.48e-35: 129: 25.00
+	Hs
		257755 SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15		MXI1_HUMAN (7-180): 1.16e-50: 165: 50.27
+	Hs
		257734 SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15		MYC_HUMAN (26-140): 2.35e-34: 128: 25.00