HitPredict

Interactor 1: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Interactor 2: SP30L (Q9HAJ7)
Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like)
Gene: SAP30L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

The method score is based on:

Property	Details
Experiments	16820529, 18070604, 21258344
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PAH~SAP30_Sin3_bdg
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 5 others more... GO:0005730 - nucleolus GO:0030336 - negative regulation of cell migration GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway GO:1902455 - negative regulation of stem cell population maintenance GO:1902459 - positive regulation of stem cell population maintenance
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	1273
Hs

1	183

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024