HitPredict

Interactor 1: CRBN (Q96SW2)
Protein cereblon
Gene: CRBN

Interactor 2: IKZF3 (Q9UKT9)
Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)
Gene: IKZF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	27294876, 26990986, 24292625, 30042095, 24292623, 24328678
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LON_substr_bdg~zf-C2H2, Yippee-Mis18~zf-C2H2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 442 Hs			1 509
+	Hs
		1033715 CRBN_HUMAN (1-442): 0: 772: 100.00		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51