HitPredict

Interactor 1: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Interactor 2: HELLS (Q9NRZ9)
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Gene: HELLS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	33170271
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0044027 - negative regulation of gene expression via chromosomal CpG island methylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 793 Hs			1 838
+	Hs
		229471 UHRF1_HUMAN (1-793): 0: 893: 100.00		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		1018648 UHRF2_HUMAN (1-793): 0: 774: 53.01		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		1299585 UHRF2_HUMAN (1-793): 0: 774: 53.01		CHD8_HUMAN (2-836): 0: 635: 26.71
+	Hs
		151512 UHRF2_HUMAN (1-793): 0: 774: 53.01		CHD2_HUMAN (5-830): 0: 596: 27.25
+	Hs
		1018602 CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		1018442 CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		1059751 CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		846950 CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1018483 CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Dm
		332724 CHDM_DROME (105-627): 2.35e-62: 230: 12.22		CHDM_DROME (41-829): 0: 596: 25.20
+	Hs
		846970 CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1059614 CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		229379 CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		229399 CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		658660 CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		658672 CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		846763 CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		846775 CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00		SMCA2_HUMAN (27-838): 0: 584: 26.37