HitPredict

Interactor 1: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Interactor 2: ARI1 (Q9Y4X5)
E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)
Gene: ARIH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ariadne~ubiquitin, IBR~ubiquitin, ubiquitin~zf-C3HC4
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding
and 2 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 793
Hs

1 557
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024