HitPredict

Interactor 1: HTF4 (Q99081)
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: TCF12

Interactor 2: NDF4 (Q9HD90)
Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3)
Gene: NEUROD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070888 - E-box binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 682 Hs			1 331
+	Hs
		1039378 HTF4_HUMAN (1-682): 0: 921: 100.00		NDF1_HUMAN (1-331): 8.63e-89: 271: 51.69
+	Hs
		1186216 HTF4_HUMAN (1-682): 0: 921: 100.00		OLIG3_HUMAN (21-275): 8.07e-39: 140: 22.57
+	Hs
		1271845 HTF4_HUMAN (1-682): 0: 921: 100.00		ATOH1_HUMAN (69-282): 4.09e-38: 140: 23.72
+	Hs
		546034 HTF4_HUMAN (1-682): 0: 921: 100.00		MYOD1_HUMAN (18-283): 1.91e-32: 124: 16.67
+	Hs
		1012646 HTF4_HUMAN (1-682): 0: 921: 100.00		MESP2_HUMAN (65-264): 1.78e-31: 123: 24.77
+	Hs
		1083176 HTF4_HUMAN (1-682): 0: 921: 100.00		TAL2_HUMAN (87-207): 2.1e-32: 118: 29.75
+	Hs
		1018388 HTF4_HUMAN (1-682): 0: 921: 100.00		TCF15_HUMAN (20-207): 4.86e-30: 115: 23.28
+	Hs
		551571 HTF4_HUMAN (1-682): 0: 921: 100.00		TFE2_HUMAN (10-189): 9.45e-28: 115: 17.10
+	Hs
		1272169 HTF4_HUMAN (1-682): 0: 921: 100.00		NGN1_HUMAN (30-227): 3.42e-29: 113: 31.00
+	Hs
		568226 HTF4_HUMAN (1-682): 0: 921: 100.00		TAL1_HUMAN (67-231): 9.24e-28: 112: 24.10
+	Hs
		1163321 HTF4_HUMAN (1-682): 0: 921: 100.00		FIGLA_HUMAN (29-222): 2.5e-28: 111: 18.63
+	Hs
		1303333 HTF4_HUMAN (1-682): 0: 921: 100.00		NGN3_HUMAN (26-205): 1.8e-28: 111: 29.03
+	Hs
		1300900 HTF4_HUMAN (1-682): 0: 921: 100.00		FER3L_HUMAN (31-152): 7.99e-29: 110: 34.92
+	Hs
		616615 HTF4_HUMAN (1-682): 0: 921: 100.00		MYF6_HUMAN (38-234): 2.02e-27: 109: 20.87
+	Hs
		1261463 HTF4_HUMAN (1-682): 0: 921: 100.00		TWST2_HUMAN (29-164): 5.02e-28: 108: 25.00
+	Hs
		210863 HTF4_HUMAN (1-682): 0: 921: 100.00		TCF21_HUMAN (32-171): 1.46e-27: 107: 24.29
+	Mm
		603985 HTF4_MOUSE (1-682): 0: 907: 92.21		TAL1_MOUSE (67-231): 6.44e-28: 112: 24.10
+	Hs
		238594 HTF4_HUMAN (1-682): 0: 921: 100.00		MUSC_HUMAN (76-151): 3.17e-21: 91.8: 36.84
+	Mm
		644476 HTF4_MOUSE (1-682): 0: 907: 92.21		TWST1_MOUSE (39-147): 3.41e-21: 91.4: 30.28
+	Mm
		603981 ITF2_MOUSE (2-682): 0: 804: 62.82		TAL1_MOUSE (67-231): 6.44e-28: 112: 24.10