HitPredict

Interactor 1: NELL2 (Q99435)
Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)
Gene: NELL2

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.532

Property	Details
Experiments	21653829
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 816 Hs			1 1731
+	Hs
		980523 NOTC2_HUMAN (400-815): 1.5e-25: 116: 19.96		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (445-815): 2.27e-24: 112: 18.75		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		804330 NOTC1_HUMAN (167-649): 2.93e-21: 102: 13.36		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		61630 MEG11_HUMAN (432-815): 4.51e-21: 101: 15.97		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1016988 FBLN3_HUMAN (432-628): 2.41e-20: 97.1: 34.12		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1231801 LTBP4_HUMAN (287-632): 1.81e-18: 92.9: 18.62		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316313 JAG2_HUMAN (510-816): 4.42e-10: 65.7: 15.26		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		166914 NOTC2_HUMAN (400-815): 1.5e-25: 116: 19.96		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		167042 NOTC3_HUMAN (445-815): 2.27e-24: 112: 18.75		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		957287 FBLN2_HUMAN (395-639): 4.04e-16: 85.1: 30.91		TNKS2_HUMAN (220-558): 1.49e-36: 153: 12.29
+	Hs
		980449 NOTC2_HUMAN (400-815): 1.5e-25: 116: 19.96		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		1237561 NOTC3_HUMAN (445-815): 2.27e-24: 112: 18.75		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		804293 NOTC1_HUMAN (167-649): 2.93e-21: 102: 13.36		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		65546 NOTCH_DROME (167-571): 2.91e-11: 69.6: 8.74		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Hs
		1231741 SORL_HUMAN (495-815): 1.24e-10: 67.7: 13.00		AN36B_HUMAN (67-198): 2.66e-16: 87.4: 18.18
+	Dm
		114000 CUBN_DROME (601-814): 1.2e-16: 87.3: 14.85		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73
+	Hs
		946786 CRUM1_HUMAN (291-477): 9.38e-11: 67.9: 19.12		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Hs
		944122 JAG1_HUMAN (158-493): 3.44e-10: 66.1: 8.55		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Dm
		422915 NOTCH_DROME (167-571): 2.91e-11: 69.6: 8.74		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Dm
		113976 M9PB30_DROME (395-635): 6.2e-13: 75.5: 29.87		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73