HitPredict

Interactor 1: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 336 Hs			1 504
+	Hs
		749954 BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79		PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00
+	Hs
		1304089 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57
+	Hs
		1281338 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Mm
		1206589 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		TBL1R_MOUSE (285-504): 8.62e-50: 180: 20.09
+	Hs
		903455 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Mm
		903677 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		WDR5_MOUSE (93-333): 2.8e-41: 152: 15.48
+	Hs
		585027 RO52_HUMAN (36-286): 4.69e-43: 156: 13.55		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		1019346 TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		749840 BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79		TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57
+	Hs
		903159 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Dm
		1279331 Q9VV77_DROME (36-334): 1.57e-34: 127: 16.50		EBI_DROME (109-424): 6.09e-70: 238: 18.37
+	Hs
		196962 BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		749764 BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		717626 BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903462 BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903492 PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		749312 BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Dm
		728797 PSC_DROME (3-336): 2.34e-33: 132: 17.31		TAF5_DROME (218-504): 3.33e-09: 61.2: 21.48