HitPredict

Interactor 1: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	32296183, 19549727, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 336 Hs			1 147
+	Hs
		849421 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919836 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895890 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1297361 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1282333 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851877 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		988038 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849312 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919711 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895781 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		988008 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		988005 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851807 RING1_HUMAN (6-336): 8.6e-69: 222: 51.24		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		849453 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919870 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895921 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1297370 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1282350 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851889 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896547 TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53