HitPredict

Interactor 1: EYA3 (Q99504)
Eyes absent homolog 3 (EC 3.1.3.48)
Gene: EYA3

Interactor 2: SIX2 (Q9NPC8)
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Gene: SIX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus GO:0009653 - anatomical structure morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 573 Hs			1 291
+	Hs
		1304296 EYA1_HUMAN (27-573): 0: 791: 52.24		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		318733 EYA4_HUMAN (23-573): 0: 787: 53.32		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Mm
		956886 EYA1_MOUSE (27-573): 0: 795: 52.70		SIX2_MOUSE (1-291): 2.19e-90: 272: 90.20
+	Hs
		92588 E9PLN6_HUMAN (20-573): 0: 782: 53.75		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Mm
		956885 EYA1_MOUSE (27-573): 0: 795: 52.70		SIX1_MOUSE (1-291): 1.55e-86: 262: 71.53
+	Hs
		1074456 EYA1_HUMAN (27-573): 0: 791: 52.24		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Hs
		318622 EYA4_HUMAN (23-573): 0: 787: 53.32		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		1143690 EYA4_MOUSE (20-573): 0: 784: 54.46		SIX1_MOUSE (1-291): 1.55e-86: 262: 71.53
+	Hs
		92587 E9PLN6_HUMAN (20-573): 0: 782: 53.75		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		956884 EYA1_MOUSE (27-573): 0: 795: 52.70		SIX4_MOUSE (5-290): 1.25e-69: 231: 44.44
+	Hs
		1230645 EYA3_HUMAN (1-573): 0: 822: 100.00		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		1304297 EYA1_HUMAN (27-573): 0: 791: 52.24		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Mm
		956887 EYA1_MOUSE (27-573): 0: 795: 52.70		SIX3_MOUSE (1-245): 3.44e-71: 224: 57.43
+	Hs
		318748 EYA4_HUMAN (23-573): 0: 787: 53.32		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Hs
		118611 EYA2_HUMAN (60-573): 0: 728: 48.84		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Mm
		936193 EYA1_MOUSE (27-573): 0: 795: 52.70		SIX5_MOUSE (1-263): 1.16e-60: 206: 45.87
+	Hs
		118562 EYA2_HUMAN (60-573): 0: 728: 48.84		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Hs
		1230644 EYA1_HUMAN (27-573): 0: 791: 52.24		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		318670 EYA4_HUMAN (23-573): 0: 787: 53.32		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		118619 EYA2_HUMAN (60-573): 0: 728: 48.84		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52