HitPredict

Interactor 1: SORT (Q99523)
Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
Gene: SORT1

Interactor 2: GGA2 (Q9UJY4)
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Gene: GGA2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	11331584, 11390366, 11821067
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0010008 - endosome membrane GO:0030136 - clathrin-coated vesicle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 831 Hs			1 613
+	Hs
		1304359 SORT_HUMAN (1-831): 0: 1064: 100.00		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Hs
		1270609 SORT_HUMAN (1-831): 0: 1064: 100.00		STAM1_HUMAN (19-524): 3.22e-96: 306: 15.76
+	Hs
		1269036 SORL_HUMAN (12-758): 0: 753: 28.52		GGA2_HUMAN (12-613): 0: 556: 100.00
+	Mm
		291365 SORL_MOUSE (12-758): 0: 738: 27.94		GGA2_MOUSE (11-613): 9.13e-178: 518: 84.74
+	Hs
		1304348 SORT_HUMAN (1-831): 0: 1064: 100.00		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Hs
		1269037 SORL_HUMAN (12-758): 0: 753: 28.52		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Sc
		687096 VPS10_YEAST (90-742): 1.85e-105: 358: 19.03		GGA2_YEAST (15-607): 3.14e-107: 336: 19.31