HitPredict

Interactor 1: SORT (Q99523)
Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
Gene: SORT1

Interactor 2: GGA1 (Q9UJY5)
ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
Gene: GGA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	11859376, 20015111, 11390366, 11821067, 20676133
Identification Methods	two hybrid, unspecified method, pull down, affinity chromatography technology, far western blotting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0010008 - endosome membrane GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 831 Hs			1 639
+	Hs
		1304348 SORT_HUMAN (1-831): 0: 1064: 100.00		GGA3_HUMAN (6-639): 3.76e-158: 473: 48.47
+	Hs
		1304358 SORT_HUMAN (1-831): 0: 1064: 100.00		GGA2_HUMAN (3-637): 9.87e-155: 461: 46.78
+	Hs
		1270609 SORT_HUMAN (1-831): 0: 1064: 100.00		STAM1_HUMAN (3-519): 4.73e-90: 291: 16.05
+	Hs
		1269037 SORL_HUMAN (12-758): 0: 753: 28.52		GGA1_HUMAN (1-639): 0: 562: 100.00
+	Hs
		1269036 SORL_HUMAN (12-758): 0: 753: 28.52		GGA2_HUMAN (3-637): 9.87e-155: 461: 46.78
+	Mm
		291365 SORL_MOUSE (12-758): 0: 738: 27.94		GGA2_MOUSE (10-631): 1.5e-151: 452: 44.70
+	Sc
		687096 VPS10_YEAST (90-742): 1.85e-105: 358: 19.03		GGA2_YEAST (2-633): 2.86e-93: 301: 20.71