HitPredict

Interactor 1: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Interactor 2: TBB2B (Q9BVA1)
Tubulin beta-2B chain
Gene: TUBB2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 947 Hs			1 445
+	Hs
		2077 M3K14_HUMAN (1-947): 0: 799: 100.00		A0A0B4J269_HUMAN (19-445): 0: 828: 91.59
+	Hs
		428380 M3K14_HUMAN (1-947): 0: 799: 100.00		TBB5_HUMAN (1-429): 0: 717: 97.44
+	Hs
		381278 M3K14_HUMAN (1-947): 0: 799: 100.00		TBB4A_HUMAN (1-427): 0: 712: 96.72
+	Hs
		1023062 STK4_HUMAN (405-650): 2.6e-99: 321: 30.80		Q6LC01_HUMAN (8-429): 0: 835: 96.21
+	Dm
		445198 AKT1_DROME (148-719): 1.12e-135: 421: 16.83		TBB3_DROME (1-445): 0: 706: 88.25
+	Dm
		1213355 AKT1_DROME (148-719): 1.12e-135: 421: 16.83		Q8MST5_DROME (1-445): 0: 705: 87.64
+	Hs
		428041 AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33		TBB5_HUMAN (1-429): 0: 717: 97.44
+	Hs
		681781 AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33		TBB4B_HUMAN (1-427): 0: 716: 98.13
+	Hs
		381125 KS6B1_HUMAN (341-818): 1.79e-124: 389: 18.20		TBB4A_HUMAN (1-427): 0: 712: 96.72
+	Rn
		871318 AAPK1_RAT (374-909): 5.75e-123: 386: 17.30		TBB4B_RAT (1-427): 0: 715: 97.89
+	Rn
		871256 AAPK1_RAT (374-909): 5.75e-123: 386: 17.30		TBB2A_RAT (1-430): 0: 713: 99.54
+	Hs
		568654 KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46		TBB3_HUMAN (1-445): 0: 720: 92.15
+	Rn
		61831 AAPK1_RAT (374-909): 5.75e-123: 386: 17.30		A6KQR9_RAT (1-427): 0: 712: 96.72
+	Hs
		568659 KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46		TBB2A_HUMAN (1-430): 0: 713: 99.54
+	Hs
		861738 PLK1_HUMAN (406-781): 1.04e-106: 345: 26.87		TBB3_HUMAN (1-445): 0: 720: 92.15
+	Hs
		1037238 KS6A2_HUMAN (319-657): 9e-97: 322: 21.49		TBB3_HUMAN (1-445): 0: 720: 92.15
+	Hs
		1037241 KS6A1_HUMAN (319-695): 1.9e-95: 318: 18.21		TBB3_HUMAN (1-445): 0: 720: 92.15
+	Hs
		933777 STK4_HUMAN (405-650): 2.6e-99: 321: 30.80		TBB4B_HUMAN (1-427): 0: 716: 98.13
+	Hs
		1023102 STK4_HUMAN (405-650): 2.6e-99: 321: 30.80		TBB6_HUMAN (1-432): 0: 714: 92.36
+	Hs
		381141 M3K8_HUMAN (379-647): 2.68e-29: 124: 30.66		TBB4A_HUMAN (1-427): 0: 712: 96.72