HitPredict

Interactor 1: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase, PH~WD40
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1358 Hs			1 779
+	Hs
		149286 CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		209479 PLRG1_HUMAN (774-1358): 1.08e-114: 371: 14.46		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1039170 KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		549923 PHKG2_HUMAN (10-342): 7.67e-79: 268: 17.10		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		148966 CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		148935 CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Hs
		149443 CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77		PKHA6_HUMAN (3-364): 2.39e-40: 162: 26.02
+	Sc
		419871 SNF1_YEAST (23-501): 2.82e-108: 358: 15.04		OSH3_YEAST (21-718): 7.21e-65: 235: 11.98
+	Mm
		659464 KCC2B_MOUSE (24-470): 6.44e-103: 340: 15.13		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Mm
		515244 KCC2A_MOUSE (24-470): 3.62e-98: 324: 15.35		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Rn
		506782 KCC2A_RAT (24-470): 3.62e-98: 324: 15.35		CNKR2_RAT (1-468): 2.97e-47: 183: 14.20
+	Hs
		1022390 KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Rn
		506741 KCC2A_RAT (24-470): 3.62e-98: 324: 15.35		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		1334862 KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		549889 PHKG2_HUMAN (10-342): 7.67e-79: 268: 17.10		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		229958 NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		787158 KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91		RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27
+	Hs
		229956 NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Hs
		229976 NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21
+	Hs
		1327337 NUAK2_HUMAN (7-311): 1.51e-67: 242: 18.91		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21