HitPredict

Interactor 1: TEAD3 (Q99594)
Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)
Gene: TEAD3

Interactor 2: VGLL1 (Q99990)
Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU)
Gene: VGLL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	32296183, 10518497, unassigned1304, 20211142
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Vg_Tdu~YBD
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 258
+	Hs
		1075216 TEAD4_HUMAN (1-435): 0: 712: 68.88		VGLL1_HUMAN (1-258): 5.64e-131: 372: 100.00
+	Hs
		658554 TEAD1_HUMAN (1-435): 0: 712: 70.58		VGLL1_HUMAN (1-258): 5.64e-131: 372: 100.00
+	Hs
		1075247 TEAD2_HUMAN (32-435): 0: 623: 64.03		VGLL1_HUMAN (1-258): 5.64e-131: 372: 100.00
+	Mm
		1143753 TEAD4_MOUSE (1-435): 0: 707: 68.42		VGLL1_MOUSE (1-229): 6.14e-97: 287: 41.50
+	Mm
		671380 TEAD1_MOUSE (1-435): 0: 713: 70.81		VGLL2_MOUSE (12-209): 6.06e-66: 209: 28.37
+	Hs
		1237699 TEAD3_HUMAN (1-435): 0: 716: 100.00		VGLL2_HUMAN (12-198): 2.69e-51: 171: 29.90
+	Hs
		67994 TEAD3_HUMAN (1-435): 0: 716: 100.00		VGLL3_HUMAN (14-171): 8.34e-40: 141: 27.55
+	Hs
		67948 TEAD1_HUMAN (1-435): 0: 712: 70.58		VGLL3_HUMAN (14-171): 8.34e-40: 141: 27.55
+	Hs
		67961 TEAD4_HUMAN (1-435): 0: 712: 68.88		VGLL3_HUMAN (14-171): 8.34e-40: 141: 27.55
+	Hs
		67962 TEAD2_HUMAN (32-435): 0: 623: 64.03		VGLL3_HUMAN (14-171): 8.34e-40: 141: 27.55