HitPredict

Interactor 1: TEAD3 (Q99594)
Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)
Gene: TEAD3

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.719

Property	Details
Experiments	16189514, 26186194, 28514442, 33961781, 31515488
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0035329 - hippo signaling GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 400
+	Hs
		1075220 TEAD4_HUMAN (1-435): 0: 712: 68.88		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		658558 TEAD1_HUMAN (1-435): 0: 712: 70.58		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		671381 TEAD1_MOUSE (1-435): 0: 713: 70.81		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		1143754 TEAD4_MOUSE (1-435): 0: 707: 68.42		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		1113240 Q3USK5_MOUSE (16-435): 0: 699: 69.16		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		936316 TEAD3_MOUSE (1-435): 0: 698: 96.58		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		671378 TEAD1_MOUSE (1-435): 0: 713: 70.81		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		808875 TEAD3_HUMAN (1-435): 0: 716: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809073 TEAD4_MOUSE (1-435): 0: 707: 68.42		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		658469 TEAD1_HUMAN (1-435): 0: 712: 70.58		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		808635 TEAD4_HUMAN (1-435): 0: 712: 68.88		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809065 TEAD3_MOUSE (1-435): 0: 698: 96.58		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		1075251 TEAD2_HUMAN (32-435): 0: 623: 64.03		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		817006 TEAD2_MOUSE (28-435): 0: 602: 62.29		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		808636 TEAD2_HUMAN (32-435): 0: 623: 64.03		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809063 TEAD2_MOUSE (28-435): 0: 602: 62.29		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		808133 TEAD2_HUMAN (32-435): 0: 623: 64.03		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Dm
		671392 SCAL_DROME (24-435): 0: 554: 56.91		YAP1_DROME (17-223): 5.05e-46: 164: 22.80
+	Sc
		576198 TEC1_YEAST (35-260): 1.25e-60: 206: 25.29		RSP5_YEAST (60-356): 4.36e-33: 133: 13.24