HitPredict

Interactor 1: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15140878, 21081666
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042113 - B cell activation GO:0045892 - negative regulation of DNA-templated transcription GO:0051091 - positive regulation of DNA-binding transcription factor activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 299 Hs			1 1122
+	Hs
		719239 PHB1_HUMAN (22-280): 1e-85: 259: 51.15		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1038661 PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1270403 PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Mm
		140199 PHB2_MOUSE (1-299): 2.46e-109: 320: 100.00		HDAC1_MOUSE (673-1103): 1.61e-153: 468: 21.16
+	Hs
		177365 PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		718831 PHB1_HUMAN (22-280): 1e-85: 259: 51.15		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1305304 PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		719208 PHB1_HUMAN (22-280): 1e-85: 259: 51.15		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		646330 STOM_HUMAN (1-286): 2.42e-84: 256: 17.93		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97