HitPredict

Interactor 1: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Interactor 2: DAXX (Q9UER7)
Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)
Gene: DAXX

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.744

The method score is based on:

Property Details
Experiments 9743501, 11495919, 27488634, 19789334, 15983381, 15258908, 11003656
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0007254 - JNK cascade
GO:0019901 - protein kinase binding
GO:0036480 - neuron intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0042803 - protein homodimerization activity
and 1 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1374
Hs

1 740
+ Mm
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024