HitPredict

Interactor 1: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30031111
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1374 Hs			1 605
+	Mm
		192187 M3K5_MOUSE (1-1372): 0: 1451: 94.13		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		1305598 M3K5_HUMAN (1-1374): 0: 1497: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Mm
		192191 M3K5_MOUSE (1-1372): 0: 1451: 94.13		FBW1B_MOUSE (96-605): 2.25e-143: 428: 85.69
+	Hs
		1163028 M3K5_HUMAN (1-1374): 0: 1497: 100.00		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		312814 M3K6_HUMAN (27-1374): 0: 1171: 43.67		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		160864 AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1027457 STK3_HUMAN (686-1116): 1.95e-98: 326: 25.39		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1023143 STK4_HUMAN (686-954): 1.73e-97: 323: 33.95		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1027451 STK3_HUMAN (686-1116): 1.95e-98: 326: 25.39		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1023136 STK4_HUMAN (686-954): 1.73e-97: 323: 33.95		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1377156 M3K2_HUMAN (685-938): 1.31e-41: 165: 40.00		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		682082 AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		160697 AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		1027412 STK3_HUMAN (686-1116): 1.95e-98: 326: 25.39		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Dm
		90543 E1JGN0_DROME (555-1374): 1.56e-137: 453: 14.41		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	At
		1105519 M3K1_ARATH (643-941): 1.3e-100: 336: 35.90		GPLPB_ARATH (309-533): 7.79e-15: 77.8: 26.07
+	At
		189011 M3K1_ARATH (643-941): 1.3e-100: 336: 35.90		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21
+	Hs
		681967 AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		1163029 M3K3_HUMAN (685-940): 1.87e-43: 171: 40.08		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		1163055 M3K2_HUMAN (685-938): 1.31e-41: 165: 40.00		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12