HitPredict

Interactor 1: ATX2 (Q99700)
Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)
Gene: ATXN2

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	18602463, 16115810, 16713569
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1313 Hs			1 347
+	Hs
		1305672 ATX2_HUMAN (1-1313): 1.72e-116: 397: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Mm
		250689 ATX2_MOUSE (1-1313): 1.28e-106: 369: 84.36		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Hs
		1217765 ATX2_HUMAN (1-1313): 1.72e-116: 397: 100.00		Q8IVP1_HUMAN (1-271): 6.83e-53: 177: 100.00
+	Hs
		1137777 OBSCN_HUMAN (105-1254): 3.4e-93: 335: 13.86		SHLB2_HUMAN (10-342): 1.05e-58: 196: 20.57
+	Mm
		88460 D3Z656_MOUSE (942-1309): 2.02e-10: 67.9: 9.92		SH3G3_MOUSE (1-346): 1.4e-88: 271: 86.71
+	Rn
		192356 SYNJ1_RAT (942-1313): 5.54e-10: 66.4: 9.97		SH3G3_RAT (1-346): 1.05e-86: 266: 86.99
+	Mm
		88459 D3Z656_MOUSE (942-1309): 2.02e-10: 67.9: 9.92		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Rn
		192354 SYNJ1_RAT (942-1313): 5.54e-10: 66.4: 9.97		SH3G2_RAT (1-347): 3.62e-85: 262: 65.63
+	Rn
		193638 SYNJ1_RAT (942-1313): 5.54e-10: 66.4: 9.97		SH3G1_RAT (1-347): 1.14e-78: 246: 66.30
+	Hs
		1052269 ATX2L_HUMAN (521-1304): 2.92e-19: 96.4: 18.02		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		1329256 TARA_HUMAN (305-1312): 2.89e-16: 87.1: 10.79		PACN2_HUMAN (1-343): 3.2e-38: 143: 16.45
+	Hs
		1315994 TARA_HUMAN (305-1312): 2.89e-16: 87.1: 10.79		PACN1_HUMAN (6-342): 5.44e-34: 131: 14.90
+	Hs
		554292 MUC1_HUMAN (699-1312): 1.2e-29: 130: 10.26		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		727262 NU214_HUMAN (72-1302): 1.38e-19: 97.9: 9.12		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		924808 MINT_HUMAN (431-1274): 9.87e-12: 72.1: 8.75		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Rn
		192744 SYNJ1_RAT (942-1313): 5.54e-10: 66.4: 9.97		SRBS2_RAT (243-342): 7.4e-12: 68.5: 21.57
+	Hs
		203228 SYNJ1_HUMAN (1080-1310): 1.58e-09: 64.8: 13.94		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		203218 SYNJ1_HUMAN (1080-1310): 1.58e-09: 64.8: 13.94		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		203192 SYNJ1_HUMAN (1080-1310): 1.58e-09: 64.8: 13.94		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Hs
		203230 SYNJ1_HUMAN (1080-1310): 1.58e-09: 64.8: 13.94		SH319_HUMAN (291-342): 6.81e-09: 59.3: 48.08