HitPredict

Interactor 1: ZNT3 (Q99726)
Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) (ZnT-3)
Gene: SLC30A3

Interactor 2: ZNT1 (Q9Y6M5)
Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)
Gene: SLC30A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	25657003
Identification Methods	bimolecular fluorescence complementation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cation_efflux~Cation_efflux
Common GO terms	GO:0005385 - zinc ion transmembrane transporter activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0046872 - metal ion binding GO:0071577 - zinc ion transmembrane transport
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 388 Hs			1 507
+	Hs
		1310024 ZNT2_HUMAN (27-386): 1.29e-121: 358: 50.82		ZNT1_HUMAN (1-507): 0: 560: 100.00
+	Hs
		157151 ZNT4_HUMAN (58-386): 2.95e-100: 305: 36.98		ZNT1_HUMAN (1-507): 0: 560: 100.00
+	Hs
		1167771 ZNT3_HUMAN (1-388): 5.56e-149: 428: 100.00		ZNT10_HUMAN (1-505): 5.56e-139: 411: 34.69
+	Mm
		1100717 ZNT2_MOUSE (21-385): 2.24e-123: 362: 50.95		ZNT10_MOUSE (1-505): 2.41e-138: 409: 35.47
+	Hs
		1167772 ZNT2_HUMAN (27-386): 1.29e-121: 358: 50.82		ZNT10_HUMAN (1-505): 5.56e-139: 411: 34.69
+	Hs
		157127 ZNT4_HUMAN (58-386): 2.95e-100: 305: 36.98		ZNT10_HUMAN (1-505): 5.56e-139: 411: 34.69
+	Hs
		157135 ZNT3_HUMAN (1-388): 5.56e-149: 428: 100.00		ZNT4_HUMAN (3-438): 2.2e-75: 245: 16.97
+	Hs
		157136 ZNT2_HUMAN (27-386): 1.29e-121: 358: 50.82		ZNT4_HUMAN (3-438): 2.2e-75: 245: 16.97
+	Hs
		1305925 ZNT3_HUMAN (1-388): 5.56e-149: 428: 100.00		ZNT2_HUMAN (3-147): 2.08e-43: 159: 25.52
+	Hs
		1305924 ZNT3_HUMAN (1-388): 5.56e-149: 428: 100.00		ZNT3_HUMAN (7-181): 1.99e-40: 151: 25.71
+	Hs
		1219479 ZNT3_HUMAN (1-388): 5.56e-149: 428: 100.00		ZNT8_HUMAN (3-143): 1.11e-31: 127: 24.82
+	Mm
		956472 ZNT3_MOUSE (1-388): 4.32e-135: 393: 89.18		ZNT2_MOUSE (3-175): 3.3e-43: 158: 26.01
+	Hs
		157098 ZNT4_HUMAN (58-386): 2.95e-100: 305: 36.98		ZNT4_HUMAN (3-438): 2.2e-75: 245: 16.97
+	Hs
		1310002 ZNT2_HUMAN (27-386): 1.29e-121: 358: 50.82		ZNT2_HUMAN (3-147): 2.08e-43: 159: 25.52
+	Hs
		1157260 ZNT5_HUMAN (23-372): 7.59e-100: 314: 18.02		ZNT6_HUMAN (251-419): 1.79e-23: 104: 19.88