HitPredict

Interactor 1: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Interactor 2: CCM2 (Q9BSQ5)
Cerebral cavernous malformations 2 protein (Malcavernin)
Gene: CCM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 0.90 0.825

The method score is based on:

Property Details
Experiments 33571521, 25982527, 27027284
Identification Methods affinity chromatography technology, x-ray crystallography, pull down, anti tag coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CCM2_C~PB1
Common GO terms GO:0005737 - cytoplasm
Homologous interactions 0

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Last updated: 15 Jul 2024