HitPredict

Interactor 1: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Interactor 2: Q9UFQ0 (Q9UFQ0)
Uncharacterized protein DKFZp434K0435
Gene: DKFZp434K0435

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 626 Hs			1 239
+	Hs
		476266 M3K3_HUMAN (1-626): 0: 606: 100.00		UBC_HUMAN (11-239): 2.58e-94: 292: 99.56
+	Hs
		476603 M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33		UBC_HUMAN (11-239): 2.58e-94: 292: 99.56
+	Hs
		475158 M3K3_HUMAN (1-626): 0: 606: 100.00		UBB_HUMAN (87-239): 3e-59: 188: 99.35
+	Hs
		924126 M3K3_HUMAN (1-626): 0: 606: 100.00		RS27A_HUMAN (163-238): 7.61e-45: 149: 100.00
+	Hs
		475248 M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33		UBB_HUMAN (87-239): 3e-59: 188: 99.35
+	Hs
		475390 AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67		UBC_HUMAN (11-239): 2.58e-94: 292: 99.56
+	Hs
		924221 M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33		RS27A_HUMAN (163-238): 7.61e-45: 149: 100.00
+	Rn
		448410 KPCD_RAT (22-625): 4.95e-139: 422: 17.43		UBC_RAT (1-191): 3.62e-69: 228: 96.34
+	Rn
		1144164 PAK2_RAT (123-624): 1.71e-125: 382: 23.53		UBC_RAT (1-191): 3.62e-69: 228: 96.34
+	At
		1091641 KIN10_ARATH (361-623): 3.5e-131: 396: 31.70		UBQ3_ARATH (1-163): 4.4e-65: 206: 95.71
+	At
		955189 KIN11_ARATH (361-624): 3.46e-129: 391: 31.58		UBQ3_ARATH (1-163): 4.4e-65: 206: 95.71
+	Hs
		474936 AKT2_HUMAN (247-622): 1.1e-127: 386: 22.40		UBB_HUMAN (87-239): 3e-59: 188: 99.35
+	Hs
		474935 AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67		UBB_HUMAN (87-239): 3e-59: 188: 99.35
+	Hs
		681773 AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67		RS27A_HUMAN (163-238): 7.61e-45: 149: 100.00
+	Hs
		475703 M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03		UBC_HUMAN (11-239): 2.58e-94: 292: 99.56
+	Hs
		476663 M3K4_HUMAN (341-624): 3.69e-51: 193: 39.10		UBC_HUMAN (11-239): 2.58e-94: 292: 99.56
+	Hs
		475017 M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03		UBB_HUMAN (87-239): 3e-59: 188: 99.35