HitPredict

Interactor 1: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Interactor 2: EGLN1 (Q9GZT9)
Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)
Gene: EGLN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 31763849, 19208626, 19147576, 17353276, 16407130, 23275444, 30487161
Identification Methods affinity chromatography technology, pull down, two hybrid, gal4 vp16 complementation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains 2OG-FeII_Oxy_3~HIF-1
Common GO terms GO:0001666 - response to hypoxia
GO:0005829 - cytosol
GO:0045944 - positive regulation of transcription by RNA polymerase II
GO:0071456 - cellular response to hypoxia
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 870
Hs

1 426
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024