HitPredict

Interactor 1: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19940151
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0071456 - cellular response to hypoxia
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 303
+	Hs
		1085720 HIF1A_HUMAN (3-868): 0: 553: 42.32		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		1085676 HIF1A_HUMAN (3-868): 0: 553: 42.32		UN45A_HUMAN (15-161): 8.39e-42: 155: 29.30
+	Hs
		1050593 SIM2_HUMAN (16-646): 3.33e-146: 448: 24.25		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		126180 BMAL1_HUMAN (1-524): 1.58e-129: 403: 20.70		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		181570 CLOCK_HUMAN (3-780): 7.98e-123: 393: 17.42		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		728969 AHR_HUMAN (5-706): 9.13e-121: 387: 16.46		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		1050583 SIM2_HUMAN (16-646): 3.33e-146: 448: 24.25		Q9BPW0_HUMAN (1-259): 2.98e-36: 137: 20.91
+	Hs
		858623 SIM2_HUMAN (16-646): 3.33e-146: 448: 24.25		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		213544 SIM2_HUMAN (16-646): 3.33e-146: 448: 24.25		SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71
+	Hs
		1306179 NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Dm
		247725 CLOCK_DROME (16-651): 1.88e-96: 326: 16.62		Q9VH81_DROME (4-246): 6.54e-32: 125: 16.87
+	Hs
		728925 AHR_HUMAN (5-706): 9.13e-121: 387: 16.46		TOM34_HUMAN (26-117): 9.37e-11: 63.5: 35.87
+	Hs
		1078485 NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12		TOM34_HUMAN (26-117): 9.37e-11: 63.5: 35.87
+	Dm
		247717 CLOCK_DROME (16-651): 1.88e-96: 326: 16.62		Q7KJA9_DROME (29-271): 2.69e-10: 63.1: 11.11