HitPredict

Interactor 1: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Interactor 2: TRI33 (Q9UPN9)
E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)
Gene: TRIM33

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23275444
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 1127
+	Hs
		1270775 EPAS1_HUMAN (1-870): 0: 863: 100.00		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Hs
		1029790 EPAS1_HUMAN (1-870): 0: 863: 100.00		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Hs
		1085711 HIF1A_HUMAN (3-868): 0: 553: 42.32		TRIM1_HUMAN (98-496): 3.35e-71: 254: 17.21
+	Rn
		193481 HIF1A_RAT (3-787): 0: 555: 43.98		CBP_RAT (517-1061): 2.66e-59: 226: 15.39
+	Hs
		1085623 HIF1A_HUMAN (3-868): 0: 553: 42.32		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Hs
		584973 HIF1A_HUMAN (3-868): 0: 553: 42.32		RO52_HUMAN (178-518): 2.8e-54: 199: 13.91
+	Hs
		1029480 HIF1A_HUMAN (3-868): 0: 553: 42.32		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Mm
		799605 BMAL1_MOUSE (1-524): 1.34e-131: 409: 20.91		CBP_MOUSE (517-1061): 2.42e-60: 229: 15.39
+	Hs
		649038 ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24		PML_HUMAN (83-635): 9.83e-61: 226: 17.01
+	Hs
		126156 BMAL1_HUMAN (1-524): 1.58e-129: 403: 20.70		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Hs
		181549 CLOCK_HUMAN (3-780): 7.98e-123: 393: 17.42		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Mm
		101411 CLOCK_MOUSE (3-672): 1.48e-120: 387: 18.59		F8VPR5_MOUSE (517-1061): 4.24e-60: 228: 15.39
+	Hs
		1219919 ARNT2_HUMAN (1-603): 2.39e-125: 395: 20.21		TRI42_HUMAN (112-581): 7.66e-59: 218: 14.95
+	Hs
		734777 ARNT2_HUMAN (1-603): 2.39e-125: 395: 20.21		TRI23_HUMAN (91-479): 1.27e-59: 217: 16.20
+	Hs
		734822 X5DP31_HUMAN (1-532): 5.09e-122: 385: 20.59		TRI23_HUMAN (91-479): 1.27e-59: 217: 16.20
+	Mm
		799600 BMAL2_MOUSE (16-475): 5.6e-113: 359: 22.11		CBP_MOUSE (517-1061): 2.42e-60: 229: 15.39
+	Hs
		1270854 NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Hs
		164359 AHR_HUMAN (5-706): 9.13e-121: 387: 16.46		TRI66_HUMAN (401-1126): 6.14e-40: 163: 20.97
+	Hs
		585104 NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47		RO52_HUMAN (178-518): 2.8e-54: 199: 13.91
+	Hs
		649099 ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20